St George's, University of London,
United Kingdom

St George's is one of Europe's largest teaching institutions for medicine and allied sciences and excels in developing outstanding practitioners of science, medicine and healthcare. It is also the only specialist health university actually based in a hospital and has been a pioneer in medicine, science and healthcare for over 250 years.
St George's mission is to create and share knowledge, inspire, train and develop people who can contribute to and improve health (and thus society) by improving disease prevention, diagnosis and treatment and shaping the future healthcare agenda.

St George's is committed to addressing gender inequality and inclusivity and works to the highest ethical standards.

St George's will oversee the study, serve as Trial Sponsor, monitor progress and provide expertise on infectious diseases and pharmacokinetic (PK) analysis.

Team members

Professor Sanjeev Krishna MA, BMChB, FRCP, DPhil, ScD, FMedSci occupies the Chair in Molecular Parasitology and Medicine at St George's. He is also a consultant physician in infectious diseases. Professor Krishna’s work has covered drug development and the physiology, resistance mechanisms, diagnosis and treatment of infectious diseases, primarily malaria. He has received funding from numerous bodies including the Medical Research Council (MRC), Wellcome Trust, the EU  as PI of the EU FP7 grant NanoMal and European and Developing Countries Clinical Trials Partnership (EDCTP), published more than 200 peer-reviewed papers and served on numerous editorial and funding boards. He has pioneered improved approaches to infectious disease treatments including groundbreaking PK studies on antimalarial drugs using classical and population approaches. He is an unpaid scientific advisor to the Foundation for Innovative New Diagnostics (FIND) and serves on the WHO's Technical Expert Group on Malaria Chemotherapy.

As a PI, he will also be a Work Package (WP) leader.

Dr Henry Staines BSc, DPhil is a Senior Research Fellow at St George's. He has broad expertise in all aspects of the molecular biology and physiology of parasitic protozoa and a particular interest in the study of parasite transporter proteins and their roles in drug resistance. He has more than 50 peer-reviewed publications to his name and co-edited a comprehensive book on antimalarial drugs (Treatment and Prevention of Malaria, Springer) with Professor Krishna (see above). Dr Staines was a co-applicant on the EU FP7 grant NanoMal and managed day-to-day aspects of that programme, including the supervision of the research assistants working on the project and the production of scientific reports. In addition to being responsible for the project's scientific management, Dr Staines also played a primary role in NanoMal’s overall management.

He will play a similar managerial and oversight role here.

Dr David Clark BSc, MSc, PhD is a post-doctoral researcher in the Institute for Infection and Immunity at St George's. He has an interest in pathogen infections, including parasites, and has published in this field. He has expertise is in molecular biology, immunology and diagnostics. During his first post-doctoral job, in UCSD, he was involved in developing therapeutics for the treatment of chronic inflammation. Since he started working at St George's, he has been involved with diagnostics projects working on leishmania, malaria and arbovirus infections.

His role in TT4CL is as the project manager.

Ms Hajnalka Kovacsevics is an experienced administrator at St George's. She has several years' experience in administering complex research programmes, including the EU FP7 grant NanoMal. In addition, she has provided administrative support for several other EU-funded grants (e.g. Antimal and MalSig under FP6), clinical trials funded by the EDCTP and a clinical trial on the treatment of colorectal cancer that was co-led by Professor Krishna. She attended a training course for administrators of FP7 grants in Budapest and gained the appropriate certification (Completion of FP7 financial and project management, 8-9 December 2011).

For this project she will provide administrative support to TT4CL.

Dr Carwyn Hooper is a Senior Lecturer in Medical Ethics and Law at St George's. With particular interests in global health ethics, research ethics and public health ethics, he has published widely on a broad range of topics to do with medical ethics, medical law and medical education. He is a trustee of the Institute of Medical Ethics (IME) and chairs its Research Committee. He is also a member of the UNESCO Chair in Bioethics Research Department. For the last five years he has served as an ex officio member of the St George’s Clinical Ethics Committee. Dr Hooper also is also deeply committed to public engagement and widening participation activities.

He will oversee the project's ethical considerations.

Jane Boland